More tools for our toolkit: The application of HEL-299 cells and dsRNA-nanoparticles to study human coronaviruses in vitroArticle Published on 2022-11-012022-11-15 Journal: Virus research [Category] SARS, 치료법, 치료제, [키워드] ACE2 receptor Analysis Antiviral antiviral genes antiviral response antiviral therapy can be used Cell cell line cells Combination competent Complete coronavirus Coronavirus replication CXCL10 cytidylic acid double-stranded expand fibroblast Gene Expression HCoV-229E HCoV-NL63 help Human human coronavirus human coronaviruses human lung IFN IFNs IFNβ in vitro increase in inducer Infection inhibit innate immune interferons ISG15 limit MERS-CoV Nanoparticles Pathogens Poly I:C. post infection PROTECT provided required SARS-CoV-2 SARS-CoV-2 pandemic stimulate translated Treatment Type I IFN type I interferon virus production were infected while [DOI] 10.1016/j.virusres.2022.198925 PMC 바로가기
Flipped over U: structural basis for dsRNA cleavage by the SARS-CoV-2 endoribonuclease뒤집힌 U: SARS-CoV-2 엔도리보뉴클레아제에 의한 dsRNA 절단의 구조적 기초Article Published on 2022-08-122022-09-11 Journal: Nucleic Acids Research [Category] SARS, 유전자 메커니즘, 치료법, [키워드] activate Activation active site cleavage cleave coronavirus coronavirus Coronavirus replication Critical cryo-EM structure cryo-EM structures double-stranded dsRNA endoribonuclease evade form generate Host immune MDA5 mechanism Nsp15 Pattern recognition pattern recognition receptor platform processing recognize replication-transcription complex RNA SARS-CoV-2 SARS-CoV-2 Nsp15 single-stranded site-directed mutagenesis structures substrates the SARS-CoV-2 uridine Vesicle viral replication [DOI] 10.1093/nar/gkac589 PMC 바로가기 [Article Type] Article
Detection of SARS-CoV-2 intra-host recombination during superinfection with Alpha and Epsilon variants in New York City뉴욕시에서 알파 및 엡실론 변이체로 중복 감염 중 SARS-CoV-2 숙주 내 재조합 검출Article Published on 2022-06-252022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, 치료법, 치료제, [키워드] allele Alpha Alpha variant B.1.1.7 B.1.429 classic coding regions Coronavirus replication detection Diversity Epsilon feasible full genome sequencing functions generate genetic diversity Genome genome sequence genomes Haplotype Host identify independent individual infect New York City nucleocapsid Occurrence ORF pathogen Pathogens Recombination reveal S gene SARS-CoV-2 superinfection Support variant virus [DOI] 10.1038/s41467-022-31247-x PMC 바로가기 [Article Type] Article
Visualizing a Field of Research for the Coronavirus Replication in Humans with Knowledge Mapping: Evidence from Web of Science지식 매핑으로 인간의 코로나바이러스 복제 연구 분야 시각화: Web of Science의 증거Article Published on 2022-06-012022-09-11 Journal: Interdisciplinary sciences, computational life sci [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] analysis Apoptosis apoptotic assembly cause caused Cell cell receptor Clustering cognitive coronavirus coronavirus Coronavirus replication COVID-19 damaged database Evolution Factors fatal disease feature field Frequency fusion gene sequence global health security globe host adaptation hotspot Human humans indicated inhibit Knowledge mapping living environment mapping mechanism MERS mutant Mutation mutations outbreak package pathogenicity Prevent promote R software Replication replication mechanism Research respiratory diseases S protein severe respiratory disease severe respiratory diseases spike Spike protein Spread the epidemic Transmission unique Variation viral infection Viral protein viral replication virus Virus evolution virus infection Web of Science Web of Science. widespread zone [DOI] 10.1007/s12539-022-00504-4 PMC 바로가기 [Article Type] Article
The SARS-CoV-2 main protease doesn’t induce cell death in human cells in vitroSARS-CoV-2 주요 프로테아제는 시험관 내에서 인간 세포에서 세포 사멸을 유도하지 않습니다Article Published on 2022-05-242022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, 치료제, [키워드] 3CL 3CLpro acute respiratory syndrome acute respiratory syndrome coronavirus addition analyzed antiviral therapies Apoptosis Cell cell death cell line cell lines contribute coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus replication COVID-19 Cytopathic effect cytotoxicity detect develop effective enzyme expression homologous human cell human cell lines in vitro inactivated induce molecular mechanism molecular mechanisms morphology multifunctional Pathogenesis protease Protein proteolytic activity required SARS-CoV SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 pathogenesis severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown Spread the SARS-CoV-2 therapeutic target unlikely variant viability viral infection [DOI] 10.1371/journal.pone.0266015 PMC 바로가기 [Article Type] Article
Repurposing the natural compounds as potential therapeutic agents for COVID-19 based on the molecular docking study of the main protease and the receptor-binding domain of spike protein주요 프로테아제 및 스파이크 단백질의 수용체 결합 도메인에 대한 분자 도킹 연구를 기반으로 천연 화합물을 COVID-19의 잠재적 치료제로 용도 변경Article Published on 2022-05-162022-09-11 Journal: Journal of molecular modeling [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] 3CLpro ACE2 active site acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin benfotiamine binding binding site Cell Compound Control coronavirus Coronavirus replication COVID-19 cysteine cysteine protease docking drug Drug discovery enzyme Folic acid fursultiamine Host human Angiotensin-converting enzyme identify in silico inhibiting K417 life cycle main protease molecular docking molecular dynamics Molecular dynamics simulation potential therapeutic agent protease Protein R403 RBD receptor Receptor-binding domain receptor-binding domain. Replication repurposing residue Riboflavin S protein S-protein S-RBD Safe SARS-CoV-2 SARS-CoV-2 entry severe acute respiratory syndrome Coronavirus Spike protein target the RBD the receptor-binding domain Vitamin vitamin B12 vitamins Y449 [DOI] 10.1007/s00894-022-05138-3 PMC 바로가기 [Article Type] Article
Development of a colorimetric assay for the detection of SARS-CoV-2 3CLpro activitySARS-CoV-2 3CLpro 활성 검출을 위한 비색 분석법 개발Article Published on 2022-04-292022-09-11 Journal: Biochemical Journal [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] 3CLpro acute respiratory syndrome coronavirus assay development. AuNP causative agent cellular conditions coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 Coronavirus replication COVID COVID 19 COVID-19 detect development diagnostic diagnostic test diagnostic testing disease ENCODE exogenously expressed global pandemic gold Gold nanoparticle HEK293T highlight human cells in vitro inactive mutant peptide point-of-care protease Protease activity Protein purified respiratory SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection sensitivity severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 virus [DOI] 10.1042/BCJ20220105 PMC 바로가기 [Article Type] Article
Synthesis of Dihydrobenzofuro[3,2-b]chromenes as Potential 3CLpro Inhibitors of SARS-CoV-2: A Molecular Docking and Molecular Dynamics StudySARS-CoV-2의 잠재적인 3CLpro 억제제로서의 디하이드로벤조푸로[3,2-b]크로멘 합성: 분자 도킹 및 분자 역학 연구Article Published on 2022-04-202022-09-11 Journal: ChemMedChem [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CLpro 3CLpro inhibitors acute respiratory syndrome acute respiratory syndrome coronavirus approach Bioactivity bioinformatics caused chymotrypsin Clustering analysis Compound Control coronavirus Coronavirus replication COVID-19 cysteine cysteine protease derivatives drug target Dynamics enzyme flavonoid flavonoids fused fused flavonoids Health in-silico Infection inhibitor inhibitor N3 inhibitors life cycle MERS-CoV methodology Middle East Middle East respiratory syndrome Coronavirus molecular molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulation. molecular interaction pandemic Potential Protein raised respiratory syndrome coronavirus SARS-CoV SARS-CoV-2 severe acute respiratory syndrome Coronavirus synthesis therapeutic Toxicity unavailability viral life cycle [DOI] 10.1002/cmdc.202100782 PMC 바로가기 [Article Type] Article
SARS-CoV-2 M pro inhibitors: identification of anti-SARS-CoV-2 M pro compounds from FDA approved drugsArticle Published on 2022-04-012022-10-04 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 신약개발, [키워드] Analysis anti-SARS-CoV-2 binding affinity binding free energy caused complex Compound Coronavirus replication Correlation analysis COVID-19 COVID-19 pandemic cysteine protease database docking drug Drug discovery Drug repurposing end point enzyme FDA approved drug in vitro in vivo Interaction Ligand M pro molecular molecular docking Molecular dynamics simulation Molecular simulation N3 inhibitor outbreak public health R428 raised recent SARS-CoV-2 screened stability structure-based virtual screening. Teniposide viral life cycle Virtual screening VS-5584 [DOI] 10.1080/07391102.2020.1842807 PMC 바로가기 [Article Type] Article
Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against CoronavirusesArticle Published on 2022-02-102022-10-29 Journal: Journal of the American Chemical Society [Category] COVID-19, COVID19(2023년), SARS, [키워드] activity Antiviral effect assays binding complexes Compound compounds Coronavirus replication COVID-19 pandemic crystal structure develop docking drug FIVE in vitro infected cells inhibitor Inhibitory effects nanomolar affinity Outbreaks pharmacokinetic protease Protease inhibitor resulting SARS-CoV-2 Screening second selected tested the SARS-CoV-2 Virtual screening was used [DOI] 10.1021/jacs.1c08402 PMC 바로가기 [Article Type] Article